Senior Director, CMC Technical Operations, siRNA Therapeutics at Alector

Lead CMC strategy for siRNA programs, align manufacturing plans with timelines.
Drive scale-up and tech transfer of oligonucleotide DP processes (HPLC, TFF) under GMP.
Advance DP development with formulation and LNP encapsulation; risk assessments.
Oversee CDMOs, lead campaigns, manage deviations, ensure quality and regulatory alignment.
Integrate AI-enabled data analysis and digital tools into CMC to accelerate timelines.

BS/MS/PhD in Chemical Engineering, Biochemistry, or Pharmaceutical Sciences.
12+ years in CMC development in biotech with siRNA/oligonucleotide RNA therapeutics.
Expertise in oligonucleotide drug substance manufacturing, scale-up, GMP transfer.
Experience overseeing CDMO partnerships and external manufacturing in clinical-stage programs.
Strong knowledge of global regulatory expectations for CMC documentation and IND/early programs.
Excellent technical writing and communication; ability to influence cross-functional teams.

Alector is Hiring